Posted by DrDick on January 09, 2001 at 08:23:59:
|
The Senator wrote me (on the page that just was archived) about Drug Interactions with Tagamet (Cimetadine). Honestly, there are so many that it would take forever to list them here. Also, FYI, it is one of the reasons that the drug lost favor when Zantac (and later Pepcid and Axid) came out. The HMO's like it because the generic is cheap. Check the SmithKline website or the PDR. Here is some info from one source:Cimetidine, apparently through an effect on certain microsomal enzyme systems, has been reported to reduce the hepatic metabolism of warfarin-type anticoagulants, phenytoin, propranolol, nifedipine , chlordiazepoxide, diazepam, certain tricyclic antidepressants, lidocaine, theophylline and metronidazole, thereby delaying elimination and increasing blood levels of these drugs. Clinically significant effects have been reported with the warfarin (Coumadin) anticoagulants; therefore, close monitoring of prothrombin time is recommended, and adjustment of the anticoagulant dose may be necessary when cimetidine is administered concomitantly. Interaction with phenytoin (DILANTIN), lidocaine and theophylline (THEODUR)has also been reported to produce adverse clinical effects.
|
|