Look out Viagra!

Cialis is in late stages of testing.starts working in 16 minutes,gives good results when stimulated for over 24 hours,is not affected by food intake.Looks pretty good~bring it on!

http://www.businesswire.com/webbox/bw.100201/212750240.htm

Hey great infor Taxibob. Knowing the FDA it will probably be 5 years before it is available.

Seattle, April 30, 2002 --- Lilly ICOS LLC announced today that the company received an 'approvable letter' for the drug Cialis (tadalafil, IC351) from the U.S. FDA. The impotency drug Cialis is a phosphodiesterase (PDE-5) inhibitor, distinguished from Viagra by a long duration of action and great selectivity, According to the company press release, which was posted to both the ICOS and the Eli Lilly websites, FDA approval was contingent upon "...successful completion of additional clinical pharmacology studies, labeling discussions, and manufacturing inspections."

Cialis has shown in clinical trials that it works faster and lasts far longer than Viagra. But because the medicine stays in the body longer, the FDA may want Lilly and ICOS to investigate the lingering effects of the drug to see if any safety risks arise. Lilly officials in a conference call with analysts declined to describe the nature of the new Cialis clinical trials, but called them "confirmatory'' studies. One Lilly executive said the U.S. Food and Drug Administration was concerned with the potential for recreational use or abuse of erectile dysfunction drugs.

FDA Approval of Cialis now appears to be pushed back approximately one year, well into 2003, the delay being widely interpreted as a disappointment to Lilly ICOS, which had hoped to launch the product in mid-2002. Speaker-training seminars for physician experts, originally planned to coincide with a product launch and scheduled for early May, were postponed indefinitely.

Know anybody in Europe ?

November 14, 2002


Eli Lilly and Co. won approval from European regulators to sell the impotence treatment Cialis, one of the company's biggest products in development.

Investment firm Lehman Brothers of New York projects Cialis' peak annual sales at $2 billion. Indianapolis-based Lilly announced the European approval today in a statement distributed by Business Wire.

The clearance comes amid a regulatory inquiry into Lilly's manufacturing, which has delayed approval of some medications in the U.S. Lilly said last week that it resolved some quality control issues, and expects U.S. approval for Cialis in the second half of next year after it completes additional studies.

Cialis is one of five medicines for which the FDA has granted Lilly so-called approvable letters, meaning the agency plans to approve the medicines once concerns are resolved.

Lilly shares rose 81 cents to $61.10 as of 9:40 a.m. in New York Stock Exchange composite trading. The stock has fallen 22 percent this year. Shares of Bothell, Washington-based Icos rose 70 cents to $25.01 on the Nasdaq Stock Market.

After hearing rumors that nonpharmaceutical Cialis is available in some foreign countries I set out on a quest to obtain samples. Someone suggested that the steroid abusing bodybuilders have been using it to counteract there steroid induced limp dicks. So I looked in various steroid related forums and did my research and found a source claiming to sell it who had some legitimate sounding references from satisfied customers. Now, this is no on-line pharmacy selling Indian generic Viagra so it is only with the greatest reservations I even list it here. ***disclaimer*** I am not recommending anyone attempt to order Cialis from this source*** I did so at my own risk. If anyone does follow in my footsteps don't blame me if you get ripped off, arrested or poisoned. I am just saying where I got the Cialis and describing my experience, but if you are not a major risk taker like me than better to wait for pharmaceutical Cialis to come out.

To order you send an empty e-mail with the subject LIST to iiph@yahoo.com . Then you will receive and auto response with a list of available drugs and ordering instructions. The list is mostly steroids but includes Cialis 20mg. Price was only $1 per 20mg(one standard dose). $100 minimum order. Payment method was to wire transfer cash to Pakistan. So basically to order you have to Western Union wire transfer $100 to Pakistan and hope they send you what you want. The references seemed genuine so prepared to accept a loss, I sent my cash to Pakistan and e-mailed my order as per instructions. I received a e-mail back stating my order had been shipped and about a week later I received mail with a postmark and postage from China. The pills were inside with no commercial packaging or labeling or any kind of documentation. Just plain round unmarked little orange pills. The way it was packaged I think it is very unlikely customs would ever open it but if they did, they would probably think they had something allot better than Cialis. I don't think it is a crime importing Cialis but 100 unmarked orange pills would probably raise a few eyebrows in the unlikely event they were discovered by customs. I don't think I would actually get in trouble if they were discovered but it would bring more attention than I desired. Remember I'm just stating my experience. If you order it is at your own risk. This is not the same as ordering generic Viagra from India.

So in summery, I actually received my 100 pills for $100 from China after paying some guy in Pakistan. so my next question was is this stuff real. I initially debated whether I should test them on a cat or something before I took any myself but finally I got brave and swallowed one. I hadn't planned any "activities" that night so I was mainly just trying to get a feel for the pills and see if it was real. Probably about 30 minutes after taking it I began to feel congestion similar to what I get off of Viagra. This was kind of disappointing because I was hoping to avoid Viagra side effects with the Cialis. The congestion was slightly different than Viagra. Kind of more Sinus congestion than nasal congestion. It wasn't to bad though. Downloaded a few girly pictures and determined the hardware was working very well. Overall the effect was somewhat more subtile than Viagra though. Perhaps do to less pronounced flushing and other effects than I get off of Viagra. The effect was not as dramatic as Viagra, it comes on if you think about it but it's not like you are walking around all day getting wood for no reason. It works great for me though but I don't really need Viagra or Cialis to begin with, I kind of just dabble with this stuff for recreational purposes. I think some people will be disappointed in Cialis because it is more natural feeling than Viagra. Maybe a good thing but I'm sure some like the feeling of Viagra "kicking in" even if that means more side effects. Cialis kind of just works silently. I can say though it certainly has a noticeable effect even after 24 hours and maybe longer.

If anyone considers ordering from the source I listed consider my disclaimers. Do so at your own risk. I do know of two other people who received orders from this source though.

"debated whether I should test them on a cat" now that would be funny!

Considering the Pakistan/Chinese source of the tablets, it could have been rat poison for all I knew. I didn't want to poison myself on some mystery pills. But I ruled out testing on a cat because I considered the consequences had it worked. I don't think I ever want to see a cat with a 36 hour raging hardon, plus I suspect a dosage that would be fatal to me, might have little effect on a relatively indestructible cat. The pills worked out fine though. Didn't kill me. No cat's were harmed in testing. A couple of SG's did report some vaginal soreness after I took the pills though. Hopefully the Pakistani connection isn't using his profits to plot the death of us infidels. I'm sure some Chinese Triad syndicate was involved in this deal too. Certainly obtaining the Cialis before it is approved involved a trip to the shadier side of the Internet. It worked out well for me though.

I_Am_Sancho, thanks for the detailed information about your experience with Cialis. Have you tried taking a 10mg dose by cutting one of the orange pills in half? If so, how effective was the 10mg dose? Also, are the pills easy to cut in half?

I didn't try a smaller dose. 20mg seemed good to me so I had no reason to experiment with dosage. The tablets aren't scored and are just plain round fairly small pills but probably they would split pretty easily. I haven't tried.

"... I suspect a dosage that would be fatal to me, might have little effect on a relatively indestructible cat."



Sluggy Freelance

Cialis is now available in 11 European Union countries as well as Australia and New Zealand.

http://www.businesswire.com/cgi-bin/f_headline.cgi?bw.031003/230694261&ticker=LEL

Just did my first try of Cialis, purchased in Rio.
Most impressive wood I�Lve had since I was 19, if I am remembering that far back correctly Effect lasted well over 24 hrs.
On the other hand, I had trouble busting a nut, and when I did it was not all that intense; had a lot of fun trying, though. Glad I was with a non-pro, as it would have been frustrating to have a session end without getting off. Also had an acid stomach, but that could have been from something else. Wondering how things will be the second time.
Any others have similar experiences?

My experience was very similar to yours Bendejo. Cialis is also available in 10 mg doses. I will be trying them next trip to Rio.
Oh, and the press has started to call Cialis "the weekender" because of how long it lasts. I frequently get a diamond-cutting stiffy up to 4 days after taking the stuff.

I just got some Cialis on line from http://www.mastersmarketing.com/price_t.htm

They list the drugs by the active ingredient (Tadalafil) and brand name in the second column.

I think I_Am_Sancho posted this link some were on the board before.

It was $37 for 4 tablets (20mg) plus $15 shipping. That�s about $13 per dose. The shipping fee is always the same so you can save a couple of bucks buy buying more at one time.

I got the order in a little over a week shipped from the UK. These are not generic it is packaged Cialis.

Dimone


(Message edited by dimone on September 29, 2003)

Sancho-I've heard others discussing cutting the 20Mg in half but also heard that because it is time released product that this is not a good idea.

I'd probably jusy buy the 10Mg dosage if 20Mg was too much.

I have also experienced the acid indigestion and keep some Pepcid AC close at hand or even take it before the Cialis

As for the "don�t cut it" biz I question it, as a similar thing was being said about cutting Viagra, that it would oxidize and lose strength. I experimented with this, with a 50mg tab I cut in half and kept for 6 months; it was still all it should have been.

Ben, I too cut the Viagras in half and have not experienced any problems doing so. I think the difference is that Cialis is time released over a period of time and cutting it in half reduces the time released effect.

Either way, better mongering through Pharmacology...LOL

Sandman
Cialis is NOT a time release tablet. The drug just has a long half life and it's effect persists for a long time. There is no release mechanism to be destroyed by cutting it. Makers of Viagra and Levitra also both recommend against cutting in half but the drug reps all admit there is no problem doing so. They just want to discourage people from using fewer pills.

Sandman
Cialis is NOT a time release tablet. The drug just has a long half life and it's effect persists for a long time. There is no release mechanism to be destroyed by cutting it. Makers of Viagra and Levitra also both recommend against cutting in half but the drug reps all admit there is no problem doing so. They just want to discourage people from using fewer pills.

KM-I humbly defer to you on the subject. Only repeating comments made by fellow Hombres. Urban legend or fact? Who the fuck knows?

I will defer to a pharmacologists...Dr J...where are you? Can you shed any light on this topic?

Sandman
The double post was unintended. I was not TRYING to be an asshole or targeting you in particular. I know for a fact that Cialis is not a time release tablet . Just wanted to set the record straight and pass on the info for those who wanted to try half tablet to save a few bucks. Damn expensive stuff from UK. Cheap in RIO but we are not all lucky enough to be there !!

Sorry if I came across as a smartass .
I am though you know !!

KM-I didn't take your double post as being a smart ass. I have done it several times by accident (guess I am one of the PC challenged...he he).

but, you do bring up an interesting point.

You say Cialis is "Not time released"? You are right...Cialis Article-"Rosen attributes Cialis� longer-term effects to a difference in the rate at which it is chemically active in the bloodstream and eliminated from the body compared with Viagra."

another story:


Cialis, a drug being developed by Eli Lilly and Co. and Icos Corp., may be able to give men erections for 24 hours after they take the drug, or approximately 20 hours longer than Viagra can.
"Cialis has the potential to be a valuable new treatment option for men with ED [erectile dysfunction] and their partners," says Dr. Harin Padma-Nathan, a urologist with the University of Southern California and lead investigator of two studies testing the drug for the companies.

"A therapy that allows a man with ED to engage in intercourse within a 24-hour window permits the couple to regain spontaneity in their sexual relationship."

Viagra's manufacturer, Pfizer, Inc., recommends men take Viagra about one hour before engaging in sexual activity. The drug helps men get an erection if they are sexually excited in about 30 minutes, and it lasts up to four hours, the company says.

Erections Up to 24 Hours Later

In one of the studies being reported today, 61 men with mild to severe erectile dysfunction received either Cialis or a placebo in a clinical setting. The doctors were not aware which patients received the drug or the placebo until after the data was collected.

After taking the drug and looking at sexual images, the doctors measured the men's response with a RigiScan, or a device that measures the firmness and duration of erections.

The men taking the Cialis were more successful at achieving erections, even up to 24 hours later, Padma-Nathan reports.

Sixteen Minutes to Action?

In another study, 223 men took the drug or a placebo at home, in a more natural setting. The men were instructed to take the drug before engaging in sexual activity and to use a stopwatch to record the time it took to achieve an erection.

Men were able to get an erection as early as 16 minutes after taking the drug and could have a second sexual encounter up to 24 hours later, Padma-Nathan found.

The firms report no significant side effects from the drug, except headaches.

Too Soon to Tell For Public Use

Experts commenting on the studies said it was too early to tell if Cialis represented an improvement on Viagra.

"It would have to be tested head to head with Viagra rather than a placebo to see if it is better," says Dr. Michael P. O'Leary, associate professor of urology at Harvard Medical School.

More men also need to be tested to see if any side effects show up in a larger population.

The firms are continuing with larger studies of the drug and plan on doing comparison tests with Viagra, says Lacy Fitzpatrick, a spokeswoman for Icos.

The findings of these studies will be presented at the 96th annual meeting of the American Urological Association next month in Anaheim, Calif.

KM-when you are right...it's OK to be a smart-ass....LOL

I will e-mail you off-line.

Ciao

RigiScan? Where can I get a home unit? LOL

KM is absolutely correct as noted by Sandman. There is no time release.

The molecular structure is very different in Cialis where as Levitra and Viagra are almost the same. In fact Pfizer is suing Bayer Pharmaceuticals for patent infringement (good fuckin luck) because they are so similar.

I took a Cialis yesterday around 12:00 and was buried deep inside Barely Legal Pie by 2:00 yesterday afternoon. Finished her the first time around 2:30 in the afternoon. We then took about a 45-minute sudsy jacuzzi bath and then I did her a second time to completion.

Cialis is taking market share away from Viagra in countries where it is approved and should be approved in the U.S. in the next 30-60 days. One of the main hold ups is that Cialis does stay in your body longer than V and L.

I own shares in ICOS so I am bias.

I love Cialis!!!!

Bentherigid

It sounds like Cialis is available in Brazil over the counter in drug store. How are they priced compared to V?

Off2, as posted under SA chats. I bought Cialis 20mg 4 to a pack, for 93.86 Reais at Drogaria Pacheco in Rio.

I have yet to use the product, but have it handy should I need it. And got it for my friends to try. I know all the Rio guys say great things about it.

I have tried Brazilian made V, and find it less potent than American made! And never will buy Brazilian V again. "Just the garotas"! grin

Off--SF found a really good price at his Drogaria. It is usually in the $R98 to $R120 range for (4) 20MG tablets (or about $9-$12 each)

I brought a bunch back for friends on my last trip.

Still sounds like it is cheaper in Br. than in Europe though!

I'll get some on my next trip (Oct 18- Oct 21) to SP. Thanks for the information.

Who is the Dr. J. Sandman is referring to? Not me right? I'm no doctor and I don't use viagra or cialis or horny goat weed etc. I belive KM has more knowledge in this field. I just try to be a gyno now and then.

sincerely,
Dr. Dick Johnson

Genuine name brand Lilly/ICOS Cialis boxed and blister packed is available from England, mailed to America without a prescription for $37 for a box of Four 20mg tablets plus shipping at http://www.mastersmarketing.com Look under the generic name "Tadalafil" on the web page http://www.mastersmarketing.com/price_t.htm This is genuine name brand pills in sealed retail boxes and blister packs, packaged for the British marketplace. The company has proven very reliable at shipping in less than two weeks. The ordering process ask the name of you doctor but you can put anything, they do not check. I have listed my ex-wives pet cat as my doctor or Dr. Rodriguez in Tijuana, it really does not matter. You could even put your real doctor.

Ben..... Don't worry about the disclosure of this source adversely affecting your ICOS stock. Since they sell name brand product it will be good for your stock holdings if people order from there.

There are other sources for generic that are much cheaper. As low a 67 cents per 20mg tablet from China but at more risk and with greater complexity and uncertainty. It is a good source and cheap but if you order do so at your own risk. The generic source is not a pharmacy so do not expect that you are dealing with a regular company. Anyway for the adventurous types, you go to http://www.anycities.com/user1/laukee/

There are instructions for ordering. Read them very carefully and follow each step. Basically you either setup and fund a Evocash account or mail a blank money order to China for $300 and he sends you the pills in 2 to 6 weeks (usually 2 weeks but be prepared to wait 6 weeks because it can and does sometimes take that long) Risky, but that's the way to get a lifetime supply for $300. You have no recourse if the deal goes wrong. The Chinaman seems honest as far as I can tell but if you order do so at your own risk.

Within the next few months there should be a generic version available from an major Indian pharmaceutical company. I have not found a good source for these yet but once they become available, this will be the preferred "low risk generic" solution. I would guess the price for the Indian generic would settle around $2 per 20mg tablet once it becomes available.

DJ-There is a CR and Rio regular on the board that is a pharmacists. Was not alluding to you.

although, Dr. Sandman does his fair share of gyno exams as well...he he!

As usual, Thanks I Am Sancho.

Well, after my first Cialis trial I have found that Viagra isn't doing it's job like it used to. Three days after taking the Cialis, I did my usual 25mg of Viagra and it did nothing! Hmmm. Two days later I did 50mg of V and it didn't do very much. Anyone else had this experience?

On the other hand, I have been run down, getting a 'gripee' as they say down here in Brazil, so this could be a factor.

Sandman: be careful recycling hombre-based info; remember the old chestnut "a lie repeated three times is the truth."
Loved that Cialis report, lines like "It would have to be tested head to head" and "The firms report no significant side effects." Pure B&B!

Off2, another tidbit for you! I've found that those type of parmaceutical supplies are more expensive in SP. But if you're not headed to Rio or can't wait? Shop around and buy where best convenient!

Alway's ask for "desconto"!

I have purchased Cialis in Sampa right on Ave Paulista for about U.S.$7.00 a pill. The drugstore is a half a block off Rua Augusta on Ave Paulista. It even has a large sign over the counter "CIALIS 25% DESCONTO". A box of real Cialis with the seal on the box and the pills in the bubble pack is R$113 but with the 25% discount the bottom line is R$84 for a box of four. Thus the U.S.$7.00 price and no prescription needed.

I have used it several times with no effects as with Viagra. No headaches, red face or body aches. The more important part is it does work as planned. 24-36 hours of blue-steel on demand. I love it. Also no problem with the pops either! Sell your Pifzer stock!!

astroglide

Hi,
I am interested in buying Cialis through the Intenet. I am scared that I will not get the "real" thing but a knock-off.

Any feedback regarding genuine websites would be appreciated. Thanks!

Just look above at the most recent post by I_am_sancho. The place he talks about in the first paragraph MastersMarketing .com sell the real deal.

Does anyone know if Cialis is available in Bangkok, Thailand?

Cialis available in Argentina. Purchased 4 in sealed boxes for $100($28 US)on Oct. 21,2003.
You can get a slightly better price for a larger
purchase(64). Bought from Globus Farmacia, Florida 903, just two blocks from the Orleans Cafe. Speak to Ivan, the owner. He speaks perfect english.Text

just placed a Cialis order from

http://www.mastersmarketing.com/price_t.htm

24 for 237.50

$9.90 per pill. Cheapest I could find outside of the China deal which I didn't like. Many websites want about $20/pill.

The last I heard was that cialis was going to be approved in the good ole USA sometime in late '03. Anyone know if this is still on-track?

-dm

Astroglide, which direction down paulista is this drug store? I'm will be staying two blocks off of palista and augusta next week and my first stop needs to be for amo. this will be perfect because it won't be out of the way at all. thanks.

Look for farmacia with sign that says 40%, 30%, 20% off. Bunch of them in SP, cialis is R$84 for 4 pills. While in Rio, i think cialis was closer to R$120 at Pacheco. On Paulista, there is one right on corner of Pamplona but I saw so many in that area, i just happened to stay nearby.
Otherwise, while leaving Bomboa, make a left and down the street there is also a farmacia that sells all the good stuff.

I actually bought some AT Bomboa when I was there last month.

I received the brand name 20 mg Cialis I ordered on Nov 11 from

http://www.mastersmarketing.com/price_t.htm

yesterday, Nov 19.

24 @ 9.90 each including shipping.

Gee thanks Ldvee.

I was wondering why ICOS stock was up $1.25 today.

certainly a win-win-win deal

me, you, and her

I also received the brand name 20 mg Cialis I ordered on Nov 11 from

http://www.mastersmarketing.com/price_t.htm

yesterday, Nov 19.

24 @ 9.90 each including shipping. Good company -- no probs.

Cialis received the FDA's approval at 10:33am EDT on Friday 11/21/2003.

http://www.fda.gov/cder/drug/infopage/cialis/default.htm

Thank God !!!!
I can now get all the free samples I need !!!
Just rubbin it in a little. All that studying for Med school has FINALLY paid off !!!!! LOL